Role of Heme Oxygenase-1 in Cellular Adaptive Stress Response

Mercoledì 21 febbraio alle 17, nell'aula "Carnazza" della Torre Biologica (Torre ovest, piano terra), il prof. Young-Joon Surh, direttore del centro di ricerca "Tumor Microenvironment Global Core" (Seoul National University, Corea del Sud) tiene la lettura magistrale dal titolo "Role of Heme Oxygenase-1 in Cellular Adaptive Stress Response".

Il seminario è organizzato dal prof. Giovanni Li Volti, docente di Biochimica Medica (dipartimento di Scienze biomediche e biotecnologiche).

Abstract

Nitrosative stress caused by reactive nitrogen species such as nitric oxide and peroxynitrite overproduced during inflammation leads to cell death and has been implicated in the pathogenesis of many human ailments. However, relatively mild nitrosative stress may fortify cellular defense capacities, rendering cellstolerant or adaptive to ongoing and subsequent cytotoxic challenges, a phenomenon known as 'preconditioning' or 'hormesis'. One of the key components of cellular stress response is heme oxygenase-1(HO-1), the rate limiting enzyme in the process of degrading potentially toxic free heme into biliverdin, free iron and carbon monoxide. HO-1 is upregulated by a wide array of stimuli and has antioxidant, anti-inflammatory and other cytoprotective functions. This review is intended to provide readers with a welldocumented account of the research done in the area of cellular adaptive survival response against nitrosative stress with special focus on the role of HO-1 upregulation, especially through activation of the transcription factor, Nrf2.

(21 febbraio 2018)